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However, this low rate of serious events creates a false sense that all discomfort should be dismissed as "the drug working." Persistent constipation, worsening stomach pain, or escalating symptoms often get normalized as inevitable rather than reported, blurring the line between expected adjustment and situations requiring medical attention

In addition, a glycolysis intermediate, Dihydroxyacetone phosphate (DHAP), is specifically enriched in RA synovial fluid and can enhance the ability of FLS pseudopod formation by activating the RhoA/ROCK signaling pathway

Eur Neurol 2004

Retinal Tear : Often presents with sudden floaters or light flashes